| 세션명 | Graduate Student Oral Session (I) (English) |
|---|---|
| 발표장 | 제9회장 |
| 논문코드 | 1O9-1 |
| 발표일 | 2021-10-21 |
| 발표시간 | 14:00-14:15 |
| 논문제목 | Redox -Sensitive Polyglycerol Nanogels Stimulate the Photo-Responsive Cytotoxicity of a Ir(III) Complex |
| 발표자 | 이채규 |
| 발표자 소속 | 울산과학기술원 |
| 저자 | 이채규, 김병수1, 권태혁† |
| 소속 | 울산과학기술원; 1연세대학교 |
| 논문초록 | Tumor microenvironment involves more vigorous redox signaling than normal cells, which has led to the development of cancer-specific degradable nanocarriers for cytotoxic anticancer drugs. Herein, we considerably improved the cancer-specific cytotoxicity of iridium complex-based photosensitizer (TIr3) by enhancing degradation sensitivity of nanogel (IrNG) through disrupting its disulfide bonds, reflecting the irreversible oxidation of intracellular glutathione by reactive oxygen species (ROS). The encapsulated TIr3 generates excessive ROS upon exposure to extremely weak light (0.25 J/cm2), efficiently degrading IrNG. The released cytotoxic TIr3 induces cancer cell apoptosis in in-vitro and in-vivo experiments. In contrast, IrNG shows high biocompatibility in the dark, even when exposed to high glutathione levels. This photosensitizer-produced ROS-mediated irreversible breakdown of IrNG provides new insight for designing unexplored cytotoxic photosensitizer-customized nanocarriers. |
THE POLYMER SOCIETY OF KOREA